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News and events

News & events

Peter Uetz, Ph.D.

Recent papers co-authored by CSBC’s Peter Uetz, Ph.D.

December 8, 2017

Peter Uetz, Ph.D., has co-authored five papers that have been published this fall.  Dr. Uetz is an associate professor of systems biology and bioinformatics at VCU’s Center for the Study of Biological Complexity (CSBC).


Global landscape of cell envelope protein complexes in Escherichia coli
Nature Biotechnology
Published online November 27, 2017
Babu et al., including Jitender Mehla, J. Harry Caufield, Peter Uetz (2017)

https://www.nature.com/articles/nbt.4024

This is the first comprehensive analysis of membrane protein complexes in baxcteria. Dr. Jitender Mehla, postdoc in the Uetz lab, mapped the interactions among proteins of a subset of these complexes in more detail. In addition, Harry Caufield, an ILS grad student, analyzed the evolutionary conservation of these complexes across hundreds of bacterial genomes.

 

Virus-host protein-protein interactions of mycobacteriophage Giles
Scientific Reports 7: 16514
Published online November 28, 2017
Mehla J, Dedrick RM, Caufield JH, Wagemans J, Sakhawalkar N, Johnson AA, Hatfull GF, Uetz P (2017)

https://www.nature.com/articles/s41598-017-16303-7.epdf

Like any other virus, bacteriophage interact with their host by protein-protein interactions. This is the first host-virus interaction map of a mycobacteriophage, the best studied group of bacteriophages. 

The nitrogen regulatory PII protein (GlnB) and N-acetyl-glucosamine 6-phosphate epimerase (NanE) allosterically activate glucosamine 6-phosphate deaminase (NagB) in Escherichia coli.
Journal of Bacteriorology 
Published December 11, 2017
Irina A. Rodionova, Norman Goodacre, Hohan Babu, Andrew Emili, Peter Uetz, , Milton H Saier Jr. 

http://jb.asm.org/content/early/2017/12/07/JB.00691-17.short?rss=1

Although this sounds like a very drab title, it is another follow-up to an observation made in the Babu et al. 2016: we show that protein-protein interactions regulate a large number of enzymes, including several in glucosamine metabolism.


The global distribution of tetrapods reveals a need for targeted reptile conservation
Nature Ecology & Evolution 1, 1677–1682
Published October 9, 2017 
Roll, U. et al. (2017)

https://www.nature.com/articles/s41559-017-0332-2

This paper is a landmark study in biogeography that compiles and analyzes the distribution map of all reptiles in the world. Reptiles are the last group of terrestrial vertebrates (after mammals, birds, and amphibians) that are studied that way and complete the large-scale biogeographic analysis of tetrapods. This study informs us which species-rich regions need protection to maximize conservation efforts. Dr. Uetz kept track of reptile taxonomy in this study.

 

Extinct, obscure or imaginary: The lizard species with the smallest ranges
Diversity and Distributions
Published online November 23, 2017
Meiri, S. et al. (2017)

http://onlinelibrary.wiley.com/doi/10.1111/ddi.12678/full

As a side project to the previous paper, this study identifies about 1000 lizard species which are only known from their type locality, i.e. literally only from one locality at all. Many of these species have never been seen again after they were discovered, so they represent the most threatened of all species.

 

 

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